ALZHEIMER’S DISEASE, THE END CONSEQUENCE OF METABOLIC DISEASE AND NITRIC OXIDE INSUFFICIENCY
Alzheimer’s disease is one of the most feared of all diseases. Not only due to the suffering by the patients themselves but the burden it puts on family members is what makes it most feared. It is a slow debilitating disease that many people survive for many years but with absolutely no quality of life.
Today Alzheimer’s disease affects 1 in 3 people over the age of 65. There are more than 6 million Americans living with Alzheimer’s. Globally, there are 55 million Alzheimers patients and this is growing at 10 million new cases each year. It is estimated by 2050 there will be more than 139 million people with Alzheimers.
Currently it kills more than breast and prostate cancers combined. In 2020 COVID led to 17% increase in AD and dementia related deaths. The global economic costs of Alzheimer’s and other dementias is $321 billion.
Despite billions of dollars in research and drug development on Alzheimer’s, today there is still no safe and effective treatment for this disease that is very clearly defined, understood with known mechanisms of onset and progression.
The major reason, I believe, is because most drugs have been developed against the beta amyloid plaques and tau tangles that are associated with and characteristic of Alzheimers disease. We now understand that these pathologies associated with Alzheimer’s are the consequences of the disease. THEY ARE NOT THE CAUSE OF THE DISEASE. Therefore, it is no wonder why all Alzheimer’s drugs have failed and will continue to fail until there are drugs developed that get to the root cause of Alzheimer’s disease.
That is the focus of my drug development program for Alzheimer’s disease and other diseases such as cardiovascular disease and chronic wounds.
Decades of research in mouse models of Alzheimer’s and in even studying humans with Alzheimer’s, we now know what causes Alzheimer’s disease. Once we know what causes the disease, we can now begin to develop rational drug therapies to prevent, cure and treat Alzheimers’s disease. Let’s review.
Causes of Alzheimer’s Disease
As shown in the picture at the top of the page from the SPECT scan, there is a loss of regulation of blood flow parts of the brain. The holes in the brain on the SPECT scan reveal areas of the brain where there is hypoxia/ischemia, meaning insufficient circulation and a deprivation of oxygen to those areas.
This loss of regulation of blood flow is due to the loss of nitric oxide in the lining of the blood vessels of the brain. This is called endothelial dysfunction. The endothelial cells of the brain maintain a very tight junction between the cells. This is called the blood brain barrier.
Proper function of the endothelial cells is to maintain the blood brain barrier and to produce nitric oxide to maintain proper circulation and oxygen delivery to all parts of the brain. The dysfunction of endothelial cells driven by vascular risk factors associated with Alzheimer’s allows the passage of toxic substances to the cerebral parenchyma.
Uncoupling of the NOS enzyme in the endothelial cells leads to insufficient nitric oxide production causing chronic hypoperfusion that eventually causes an inflammatory and neurotoxic response.
Loss of nitric oxide production also causes insulin resistance and leads to diabetes. Alzheimer’s is now often referred to as Diabetes Type 3. If nitric oxide production is not restored, there is insulin resistance, metabolic dysfunction, chronic inflammation, oxidative stress and immune dysfunction that occurs in the brain cells.
This is the root cause of Alzheimer’s. Over time this leads to protein misfolding, toxin build up which we identify as beta amyloid plaques and tau tangles.
The end result of Alzheimer’s cannot be used as a target for drug development. Why not develop drugs against the earliest events in the onset and progression of Alzheimer’s disease?
Well now we are.
Characteristics and causes of Alzheimer’s
1. Loss of blood flow/poor cerebral circulation
2. Insulin resistance/metabolic dysfunction
3. Breakdown of blood/brain barrier
5. Oxidative Stress
6. Immune dysfunction
Correcting Alzheimer’s Disease with Nitric Oxide
Providing a source of nitric oxide and restoring the cells’ ability to produce nitric oxide corrects all aspects of Alzheimer’s disease. Nitric oxide improves cerebral blood flow. Nitric oxide improves insulin signaling and increases glucose uptake addressing the metabolic aspects of the disease. Nitric oxide helps restore endothelial function providing blood brain barrier integrity. Nitric oxide inhibits inflammation, oxidative stress and immune dysfunction.
A single molecule produced at the right dose completely corrects one of the most poorly managed diseases and most feared diseases in the world.
Nitric oxide is the key to addressing the root cause of Alzheimer’s disease and the future of drug development for Alzheimer’s. In addition, we can now offer effective lifestyle management strategies that will help prevent the age-related loss of nitric oxide production.
If you want to avoid developing Alzheimer’s, below are steps you can take to prevent loss of nitric oxide:
1. You have to exercise at least 30 minutes per day, every day. Exercise stimulates glucose uptake and burns sugar as a fuel.
2. You must avoid mouthwash, antibiotics and fluoride. All of these shut down nitric oxide production and lead to insulin resistance and diabetes.
3. You must avoid all antacids, especially proton pump inhibitors. People who have been on PPIs for more than 4 years have a 40% higher incidence of dementia and Alzheimer’s. These drugs completely shut down nitric oxide production
4. Last but not least, you need to take a nitric oxide active product in order to supply a source of nitric oxide that your body is unable to produce that also restores the oral microbiome and recouples the NOS enzyme. I happen to know how to do that.
We are working diligently to get our nitric oxide drugs through FDA clinical trials to finally provide a safe and effective treatment for Alzheimer’s and other poorly managed diseases.
Stay tuned but in the meantime, start making the changes above to see meaningful reduction in the risk of developing Alzheimer’s. We will change the world and the way we treat chronic disease.
Dr. Nathan S. Bryan is a biochemist and physiologist that has more than 20 years of basic science and clinical research. His many seminal discoveries have resulted in dozens of issued U.S. and International patents. He is an international expert in nitric oxide and molecular medicine. Dr. Bryan is an innovator and successful entrepreneur who product technology is responsible for hundreds of millions of dollars in revenue worldwide. This content is not intended to replace medical advice from a physician.